理学院学术报告-The water-soluble bicyclic 2-pyridone-based fluorescent probe for fast and selective detection of hypochlorite

报告题目：The water-soluble bicyclic 2-pyridone-based fluorescent probe for fast and selective detection of hypochlorite

报 告 人：周倩

报告时间：2023年5月26日 19:00

报告地点：化学实验中心201

主办单位：理学院

报告人简介：

周倩，博士，硕士生导师。主要从事生物荧光探针的设计、合成及应用研究。近年来，主持四川省自然科学基金面上项目1项，参与多项国家级、省部级课题，在相关领域发表SCI论文19篇，其中以第一/共同第一作者在Anal.Chem.、Chem. Commun.、Org. Chem. Front.、Chin. Chem. Lett.等国际知名刊物发表论文 8 篇（发表 在Org. Chem. Front.上的文章被收录为封面文章，发表在Anal. Chem.上的成果受邀编入Springer Protocols Handbooks系列丛书），获授权国家发明专利 2 项。

报告摘要：

As a strong oxidizer, hypochlorite (ClO^–) are widely employed as bleaching agents and disinfectants. Determination of ClO^– is required to ensure bactericidal effects and avoid hazards caused by excessive residual chlorine. Herein, the derivative bicyclic 2-pyridone, namely DHIP-Py, was prepared successfully to establish a new ClO^–-quantitative method. The probe exhibits excellent ClO^–selectivity over other ROS and anions/cations, high sensitivity (LOD = 1.32 μmol/L), fast response (<5 s), and wide-pH tolerance (pH 4∼10). Benefit from its good water solubility, DHIP-Py is well suited for water sample analysis and has been successfully applied to detect ClO^–in real-world food and environmental samples, including tap water, bottled water and river water. The detection results were essentially identical to that of obtained from traditional DPD method. Moreover, visual detection of ClO^– via filter paper-based solid sensor and imaging of ClO^– in Escherichia coli were also achieved by DHIP-Py. These satisfactory results demonstrate that this bicyclic 2-pyridone-based hypochlorite probe is a promising free chlorine chemosensor with great potential for analytical applications.